Every 72 seconds someone in America develops Alzheimer’s disease (AD). And it has been said that almost everyone living long enough will eventually show evidence of Alzheimer’s disease. Thus far its cause has remained elusive. Nevertheless, recently, study after study, in which scientists have injected human Alzheimer diseased brain tissue into mice and other laboratory animals that later developed the disease have left little doubt that Alzheimer’s arises from an infectious process, and the focus of debate seeming to be which particular disease. But clearly, it must be a disease that is not only statistically widespread in the world today, but that was also prevalent at the time of Dr. Alois Alzheimer. To be sure, it was German neuropathologist Oskar Fischer of the Prague school of Neuropathology, Alzheimer’s great rival, who was the first to suggest that infection might be causative for Alzheimer’s. Fischer’s credentials: he was the co-discoverer of Alzheimer’s disease and tirelessly did autopsies on the brains of patients with Alzheimer’s. Fischer’s infectious view never gained immediate popularity, although today, more than a century later, a volume of data supporting such an approach has begun to accumulate. But was Fischer’s specific microbe, a tubercular-like Streptothrix, on the right track to discovering the cause of Alzheimer’s to begin with? The evidence and events uncovered in this manuscript, including those of Babes, Chantemesse, Marinescu, Southard, Clouston and Schwartz seems to suggest that he was considerably closer than anyone else ― either then or since.