Pilot Zeke Blades learns that his friend and former flight instructor Ben Stone has gone missing while flying humanitarian missions in Africa for Global Health Resources. Zeke travels there in search of Ben. He meets enigmatic Tanzanian beauty Liana Sekibo and a cadre of anti-poaching vigilantes known as the Mambas. Zeke is drawn into a fight against a gang of poachers led by the outlaw Muhammadu Raza, who feeds profits from illegal ivory to al-Isra, a radical Islamist group plotting to seize Uganda.