In a wooded suburb of Southern Maryland, the victim of a drunken midnight hit-and-run accident is left to die on the side of the road, his body horribly shattered. His unconscious form, on the brink of death, is transported to one of the best trauma hospitals in the state, where he is cared for by one of the nation's leading surgeons, Dr. Paul Laden. The doctor observes something astounding about his patient, which contradicts everything he knows about medicine. This leads Dr. Laden down a dark and forbidden path of savage experimentation and exploitation. His actions open wide a door that releases a primordial evil upon an unsuspecting world. This, in turn, forces from the shadows creatures that have manipulated mankind for millennia, and they will once again walk among us. Their unholy wrath will threaten to destroy the human race.