Murder Music is the story of a quest by elderly black jazz saxophonist, Tiger Blakely, and his student, white, teen-age girl violin virtuoso, Missy McKean, to discover who is trying to murder Blakely and why. They undertake a jazz road trip after two attempts on Blakely's life, trying to escape the killer, but they are tracked and the attempts continue. Finally they solve the musical mystery and the villain is discovered and arrested with the help of a secret service agent who has fallen in love with Missy. But when the miscreant escapes, their lives are threatened during Missy's debut as a professional violinist.