This booklet describes an approach to the process of grief and adjustment to change that is grounded in neuroscience. It’s no-nonsense, and goes right to the bare bones of what the process of grief or adjustment really is. Grief and adjustment to change are hard enough as it is. There is no need to make it worse by also worrying that we are going crazy, or that there is something wrong with us. When people understand how grief and adjustment to a big life change affect their brain, they worry less about what they are feeling. This booklet is based on an earlier paper that was originally intended for GPs. Over the years it has become a useful resource for my clients, their family members and friends. I thought it was time to make it available to everyone. This approach to grief and adjustment to change is accessible and can be helpful to people of all ages, including children and young people.