Bam Matthews, an FBI agent on his way out the door, is working the case of a drug deal gone sour when he and his partner encounter a dying man in a hotel parking garage. The man was a Belgian diplomat who it is later determined, died of Ebola. Several of the bystanders and Bam's partner are quarantined with symptoms. The Belgians send a representative to arrange for the disposition of the diplomat's remains. Bam, currently without a partner and on his higher-up’s shit list, is assigned to chauffeur her around the city. When there are delays in releasing the body and more cases popping up, she and Bam strike a deal. She will help him with his murder case if he helps her find out how a man whose life she was responsible for could have died of Ebola in Philadelphia.