In our rush to acceptance of innovative trends, products and solutions, we are frequently discovering that our embrace of “new” comes with consequences—positive and negative. Innovations are changing our cultures, spearheading movements, and even, altering a foundation of human interaction and touch. Today, we can create artificial intelligence, augmented realities, global dialogues, risk mitigations, terrorism responses, and even download our brains into “the cloud”. Yet, are we prepared for the impacts of these innovations? Do we comprehend what influence they have on our decisions? Are these innovations all necessary, and is it contributing to wealth divides? Innovation ramifications have been here for centuries—now they arrive at a non-stop pace. Personal and cultural dependence on innovations, at a time of rising nationalism and populism, will usher in startling consequences shattering ideals of business, ethics, strategy, behaviors, and individual privacy. Are we prepared for the shifts of wealth that will come with innovations? Where will we draw the “red lines” on privacy and the big data collection across every aspect our of lives? Will we become mere extensions of our innovations, addicted to their benefits, while ignoring the ramifications? The innovations we cherish and the embrace of “everything that is new”, is leading to tremendous challenges with the dawn of the Fourth Industrial Revolution—where intelligent innovations will dominate our lives, fantasies, dialogues, and relationships. Who decides the ethics of innovations? Are we putting our faith, our lives in governments, politicians, or self-policing firms?