Eight years have passed since the events of the Trinity, with the remaining descendants of the Round Table of Knights working in harmony alongside The Sacred Band warriors, led by Adam Allen. A new threat arrives unlike anything either the Knights or The Sacred Band has experienced before - a deadly virus that appears very selective in its victims and is rapidly becoming a modern Black Death. At its head are the two remaining children of Queen Niobe, born from the historic ruling House of Thebes and with a vendetta against both the Gods and humanity.